BDBM50152917 CHEMBL361376::N-Hydroxy-2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-oxetan-3-yl}-acetamide

SMILES Cc1cc(COc2ccc(cc2)S(=O)(=O)CC2(CC(=O)NO)COC2)c2ccccc2n1

InChI Key InChIKey=JTEXDSSTTHRJGK-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50152917   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152917(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
Affinity DataIC50:  595nMAssay Description:Effect on TNF-Alpha release in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50152917(CHEMBL361376 | N-Hydroxy-2-{3-[4-(2-methyl-quinoli...)
Affinity DataIC50:  1nMAssay Description:Inhibition of porcine Tumor necrosis factor- alpha converting enzyme (TACE, ADAM17)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed